Association of Antibody Responses to Fusobacterium nucleatum and Streptococcus gallolyticus Proteins with Colorectal Adenoma and Colorectal Cancer

Streptococcus gallolyticus subspecies (SGG) and Fusobacterium (F.) nucleatum have been implicated in colorectal carcinogenesis. Here, the association of immune responses to bacterial exposure with advancing stages neoplasia was assessed by multiplex serology. Immunoglobulin (Ig) A G antibody eleven proteins each F. SGG were measured plasma controls (n = 100) patients cancer (CRC, n 25), advanced adenoma 82), or small polyps 85). Multivariable logistic regression used evaluate sero-positivity neoplasia. In a cohort subset matched data 45), correlated abundance both neoplastic normal tissue. IgG Fn1426 associated an increased CRC risk (OR 4.84; 95% CI 1.46–16.0), while IgA any protein specifically Gallo0272 Gallo1675 alone occurrence 2.02, 1.10–3.71; OR 2.67, 1.10–6.46; 6.17, 1.61–23.5, respectively). Only mucosa positively response antigen (Correlation coefficient (r) 0.38, p < 0.01). Antibody adenomas CRC, respectively. Further studies are needed clarify role these microbes their antigens may carcinogenesis stages.